Endometrial Immunology and pregnancy

The endometrial immunology test allows the detection of immune alterations that may prevent embryo implantation and interfere with the development of the pregnancy.

We now know that there are many other factors that are involved in the success of a fertility treatment apart from the embryo quality and the endometrium. Within these causes of failure, we have discovered that immunology – the way the woman’s body reacts to pregnancy – is key for implantation and the future of the pregnancy.

The endometrial immune system is essential in the process of embryo nesting and pregnancy development. When pregnancy occurs, there must also be a dialogue between the maternal immune system and the embryo. This molecular relationship interferes with implantation for the pregnancy to progress. An unbalanced immune system can lead to implantation failure and repeated miscarriages.

There are three types of diagnosis that allow us to detect failures in this immune response that allow us to establish lines of treatment for implantation failure and repeat miscarriage. These are the endometrial implantation window, endometrial cell profiles (NK cells), and embryo/mother compatibility tests based on HLA-C molecules and KIR receptors.

For whom is it?

The endometrial immunological test is useful in IVF treatments, Ovodonation, Embryo donation and ROPA method in which embryo transfer is performed. Generally, this test will be indicated in the following cases:

  • Implantation failures in previous treatments with good quality embryo transfer.
  • Repeated miscarriages.
  • Infertility of unknown origin.

With a complete evaluation of your case, the Vida Fertility Institute team will guide you on which tests are necessary to identify fertility problems. The immunological test can be completed with the Endometrial Receptivity test.

How the is Endometrial
Immunology test process?

This immunological test consists of the endometrial preparation of the patient and a biopsy of the endometrial tissue at a specific time in the cycle.

When the sample has been obtained, it is sent to the molecular laboratory and we proceed to study the expression of endometrial immune cells. With this study, we evaluate whether the endometrium is ready to receive the embryo and whether implantation is correct from an immunological point of view.

The technique used is flow cytometry, which helps us to determine the state of the patient’s immune balance and to assess whether immunotherapy is required to restore this cellular balance.