Endometrial Immunology

Endometrial Immunology and pregnancy

Thanks to the endometrial immunology test, we know that in addition to the quality of the embryo and the endometrium, many other factors are involved in the success of a fertility treatment. Among the causes of failure, we have discovered that immunology, i.e. the way in which the woman’s body reacts to pregnancy, is decisive for the embryo implantation and the proper development of the pregnancy.

To achieve an on-going pregnancy, there must be a dialogue between the immunological system of the endometrium and the embryo. This molecular relationship plays a role in implantation and in the development of the pregnancy. An unbalanced immune system can lead to repeated implantation failures and miscarriages.

With this immunological test, we will be able to identify functional defects in the endometrium, as well as the presence of immune cells in the endometrium, especially NK cells (Natural Killers Cells) and their receptors called KIR, which recognise HLA-C molecules responsible for identifying foreign bodies that may cause the embryo to be rejected.

endometrial inmulogy
for who its tesa

Who is it for?

The endometrial immunological test is useful in IVF treatments, Egg donation, Embryo donation and ROPA method, whenever there is an embryo transfer. Generally, this test will be indicated in the following cases:

 -History of implantation failure in previous treatments after transfer of good quality embryos.

-Repeated miscarriages.

-Unexplained infertility.

After a full assessment of your case, Vida Fertility specialists will direct you towards the necessary tests to identify your fertility problems. The immunological test can be combined with the Endometrial Receptivity Test.

How the is Endometrial Immunology test process?

This immunological test consists of the endometrial preparation of the patient and a biopsy of the endometrial tissue at a specific time during the cycle.

When the sample has been collected, it is sent to the molecular laboratory which studies the expression of endometrial immune cells. With this study, we evaluate whether the endometrium is ready to receive the embryo for a successful implantation from an immunological point of view.

The technique used is flow cytometry, which helps us to determine the state of the patient’s immune balance and to assess whether immunotherapy is required to restore this cellular balance.

how is the endometrial process